| City | Region | Population | Latitude | Longitude |
|---|---|---|---|---|
| Asunción | Asunción | 1,482,200 | -25.3006600 | -57.6359100 |
| Ciudad del Este | Alto Paraná | 320,782 | -25.5097200 | -54.6111100 |
| San Lorenzo | Central | 227,876 | -25.3396800 | -57.5087900 |
| Capiatá | Central | 198,553 | -25.3552000 | -57.4454500 |
| Lambaré | Central | 126,377 | -25.3468200 | -57.6064700 |
| Fernando de la Mora | Central | 120,167 | -25.3386000 | -57.5216700 |
| Limpio | Central | 96,143 | -25.1661100 | -57.4856200 |
| Nemby | Central | 94,641 | -25.3949000 | -57.5357400 |
| Pedro Juan Caballero | Amambay | 75,109 | -22.5472200 | -55.7333300 |
| Encarnación | Itapúa | 74,983 | -27.3305600 | -55.8666700 |
| Mariano Roque Alonso | Central | 72,008 | -25.2079100 | -57.5320200 |
| Itauguá | Central | 64,997 | -25.3925800 | -57.3542100 |
| Villa Elisa | Central | 64,099 | -25.3676000 | -57.5927400 |
| Villa Hayes | Presidente Hayes | 57,217 | -25.0930600 | -57.5236100 |
| San Antonio | Central | 55,754 | -25.4212600 | -57.5472500 |
| Caaguazú | Caaguazú | 54,808 | -25.4500000 | -56.0166700 |
| Presidente Franco | Alto Paraná | 54,292 | -25.5638400 | -54.6109700 |
| Coronel Oviedo | Caaguazú | 51,286 | -25.4444400 | -56.4402800 |
| Concepción | Concepción | 48,123 | -23.3998500 | -57.4323600 |
| Villarrica | Guairá | 41,157 | -25.7494600 | -56.4351800 |
| Pilar | Ñeembucú | 28,716 | -26.8687900 | -58.2934600 |
| Caazapá | Caazapá | 23,996 | -26.1958300 | -56.3680600 |
| Caacupé | Cordillera | 21,696 | -25.3857500 | -57.1421700 |
| Itá | Central | 18,459 | -25.5005400 | -57.3671700 |
| San Juan Bautista | Misiones | 16,593 | -26.6694400 | -57.1458300 |
| Nueva Esperanza | Canindeyú | 12,717 | -24.5076000 | -54.8551000 |
| Juan de Ayolas | Misiones | 12,061 | -27.3866200 | -56.8472400 |
| Santa Rita | Alto Paraná | 11,823 | -25.7833300 | -55.0666700 |
| Colonia General Alfredo Stroessner | Caaguazú | 11,558 | -25.3666700 | -55.7000000 |
| Areguá | Central | 11,222 | -25.3125000 | -57.3847200 |
| San Isidro de Curuguaty | Canindeyú | 11,095 | -24.4718400 | -55.6922700 |
| Horqueta | Concepción | 10,531 | -23.3427800 | -57.0597200 |
| Lima | San Pedro | 10,367 | -23.9000000 | -56.3333300 |
| Piribebuy | Cordillera | 10,337 | -25.4649800 | -57.0418300 |
| Paraguarí | Paraguarí | 10,079 | -25.6208300 | -57.1472200 |
| Tobatí | Cordillera | 9,952 | -25.2611100 | -57.0832900 |
| Ypacarai | Central | 9,655 | -25.4077700 | -57.2888900 |
| San Pedro de Ycuamandiyú | San Pedro | 9,360 | -24.0853400 | -57.0874500 |
| Capitán Bado | Amambay | 9,114 | -23.2666700 | -55.5333300 |
| Guarambaré | Central | 9,065 | -25.4909600 | -57.4556700 |
| Eusebio Ayala | Cordillera | 8,253 | -25.3827600 | -56.9608800 |
| Filadelfia | Boquerón | 8,048 | -22.3393600 | -60.0315700 |
| San Juan Nepomuceno | Caazapá | 7,893 | -26.1122900 | -55.9386100 |
| Benjamín Aceval | Presidente Hayes | 7,751 | -24.9666700 | -57.5666700 |
| Doctor Juan León Mallorquín | Alto Paraná | 7,481 | -25.4000000 | -55.2666700 |
| Salto del Guairá | Canindeyú | 7,385 | -24.0625000 | -54.3069400 |
| Santa Rosa Misiones | Misiones | 7,257 | -26.8873000 | -56.8490500 |
| Yaguarón | Paraguarí | 7,181 | -25.5613900 | -57.2834300 |
| Repatriación | Caaguazú | 7,085 | -25.5333300 | -55.9500000 |
| Obligado | Itapúa | 6,350 | -27.0333300 | -55.6333300 |
| Emboscada | Cordillera | 5,911 | -25.1500000 | -57.3500000 |
| Carapeguá | Paraguarí | 5,784 | -25.8000000 | -57.2333300 |
| San Pedro del Paraná | Itapúa | 5,722 | -26.8326800 | -56.2057500 |
| Bella Vista | Amambay | 5,653 | -22.1333300 | -56.5166700 |
| Colonia Menno | Boquerón | 5,615 | -22.3666700 | -59.8166700 |
| Nanawua | Presidente Hayes | 5,587 | -25.2793000 | -57.7030700 |
| Arquitecto Tomás Romero Pereira | Itapúa | 5,533 | -26.4833300 | -55.2500000 |
| Hohenau | Itapúa | 5,306 | -27.0731500 | -55.6424700 |
| Quiindy | Paraguarí | 5,137 | -25.9760600 | -57.2335300 |
| Puerto Rosario | San Pedro | 5,123 | -24.4500000 | -57.0833300 |
| San José | Caaguazú | 5,117 | -25.5333300 | -56.7333300 |
| San Alberto | Alto Paraná | 4,989 | -24.9666700 | -54.9000000 |
| Doctor Juan Manuel Frutos | Caaguazú | 4,797 | -25.3666700 | -55.8000000 |
| Yuty | Caazapá | 4,774 | -26.6147100 | -56.2460700 |
| Atyrá | Cordillera | 4,768 | -25.2787600 | -57.1719200 |
| Altos | Cordillera | 4,763 | -25.2626300 | -57.2544300 |
| Puerto Mayor Otaño | Itapúa | 4,701 | -26.4000000 | -54.7000000 |
| San Bernardino | Cordillera | 4,651 | -25.3106700 | -57.2962800 |
| Ybycuí | Paraguarí | 4,629 | -26.0166700 | -57.0500000 |
| Iturbe | Guairá | 4,475 | -26.0500000 | -56.4833300 |
| La Paloma | Canindeyú | 4,383 | -24.1295700 | -54.6137600 |
| Carmen del Paraná | Itapúa | 4,196 | -27.2223200 | -56.1524300 |
| General Artigas | Itapúa | 4,073 | -26.9352200 | -56.2216800 |
| Colonia Catuete | Canindeyú | 4,070 | -24.1333300 | -54.6166700 |
| Pirayú | Paraguarí | 4,000 | -25.4840600 | -57.2349000 |
| Fram | Itapúa | 3,916 | -26.9833300 | -55.8833300 |
| Itacurubí del Rosario | San Pedro | 3,887 | -24.5354100 | -56.8235200 |
| Itacurubí de la Cordillera | Cordillera | 3,576 | -25.4615800 | -56.8533300 |
| Capiíbary | San Pedro | 3,537 | -24.8000000 | -56.0333300 |
| Colonia Yguazú | Alto Paraná | 3,363 | -25.4500000 | -55.0000000 |
| Acahay | Paraguarí | 3,205 | -25.9166700 | -57.1500000 |
| Itakyry | Alto Paraná | 3,038 | -24.9861100 | -55.1496300 |
| Abaí | Caazapá | 3,024 | -26.0333300 | -55.9333300 |
| General Elizardo Aquino | San Pedro | 2,983 | -24.4441700 | -56.9006100 |
| Nueva Italia | Central | 2,841 | -25.6108000 | -57.4656300 |
| Trinidad | Itapúa | 2,837 | -27.1166700 | -55.7833300 |
| Colonia Neuland | Boquerón | 2,816 | -22.6666700 | -60.1166700 |
| Ygatimi | Canindeyú | 2,809 | -24.1237100 | -55.6441800 |
| Los Cedrales | Alto Paraná | 2,754 | -25.6500000 | -54.7000000 |
| Antequera | San Pedro | 2,701 | -24.1333300 | -57.0833300 |
| La Colmena | Paraguarí | 2,551 | -25.8862700 | -56.8408400 |
| Jesús | Itapúa | 2,530 | -27.0559800 | -55.7413000 |
| Capitán Miranda | Itapúa | 2,498 | -27.2000000 | -55.8000000 |
| Fuerte Olimpo | Alto Paraguay | 2,475 | -21.0415300 | -57.8737700 |
| Carayaó | Caaguazú | 2,473 | -25.1833300 | -56.4000000 |
| Arroyos y Esteros | Cordillera | 2,455 | -25.0547800 | -57.0987300 |
| Tacuatí | San Pedro | 2,405 | -23.4500000 | -56.5833300 |
| Colonia Mauricio José Troche | Guairá | 2,368 | -25.5666700 | -56.2833300 |
| Bella Vista | Itapúa | 2,334 | -27.0500000 | -55.5500000 |
| Villa Florida | Misiones | 2,305 | -26.3833300 | -57.1500000 |