| City | Region | Population | Latitude | Longitude |
|---|---|---|---|---|
| Guatemala City | Guatemala | 994,938 | 14.6407200 | -90.5132700 |
| Mixco | Guatemala | 473,080 | 14.6333300 | -90.6063900 |
| Villa Nueva | Guatemala | 406,830 | 14.5269400 | -90.5875000 |
| Petapa | Guatemala | 141,455 | 14.5027800 | -90.5516700 |
| San Juan Sacatepéquez | Guatemala | 136,886 | 14.7188900 | -90.6441700 |
| Quetzaltenango | Quetzaltenango | 132,230 | 14.8347200 | -91.5180600 |
| Villa Canales | Guatemala | 122,194 | 14.4813900 | -90.5316700 |
| Escuintla | Escuintla | 103,165 | 14.3050000 | -90.7850000 |
| Chinautla | Guatemala | 97,172 | 14.7083300 | -90.4994400 |
| Chimaltenango | Chimaltenango | 82,370 | 14.6611100 | -90.8194400 |
| Chichicastenango | Quiché | 79,759 | 14.9333300 | -91.1166700 |
| Huehuetenango | Huehuetenango | 79,426 | 15.3191800 | -91.4724100 |
| Amatitlán | Guatemala | 71,836 | 14.4774000 | -90.6348900 |
| Totonicapán | Totonicapán | 69,734 | 14.9116700 | -91.3611100 |
| Santa Catarina Pinula | Guatemala | 67,994 | 14.5688900 | -90.4952800 |
| Santa Lucía Cotzumalguapa | Escuintla | 62,097 | 14.3333300 | -91.0166700 |
| Puerto Barrios | Izabal | 56,605 | 15.7277800 | -88.5944400 |
| San Francisco El Alto | Totonicapán | 54,493 | 14.9500000 | -91.4500000 |
| Cobán | Alta Verapaz | 53,375 | 15.4708300 | -90.3708300 |
| San José Pinula | Guatemala | 47,247 | 14.5461100 | -90.4113900 |
| San Pedro Ayampuc | Guatemala | 46,803 | 14.7866700 | -90.4511100 |
| Jalapa | Jalapa | 45,834 | 14.6347200 | -89.9888900 |
| Coatepeque | Quetzaltenango | 45,654 | 14.7000000 | -91.8666700 |
| Sololá | Sololá | 45,373 | 14.7722200 | -91.1833300 |
| Mazatenango | Suchitepeque | 44,132 | 14.5341700 | -91.5033300 |
| Chiquimula | Chiquimula | 41,521 | 14.8000000 | -89.5458300 |
| San Pedro Sacatepéquez | San Marcos | 40,021 | 14.9666700 | -91.7666700 |
| Salamá | Baja Verapaz | 40,000 | 15.1027800 | -90.3180600 |
| Antigua Guatemala | Sacatepéquez | 39,368 | 14.5611100 | -90.7344400 |
| Retalhuleu | Retalhuleu | 36,656 | 14.5361100 | -91.6777800 |
| Zacapa | Zacapa | 36,088 | 14.9722200 | -89.5305600 |
| Jutiapa | Jutiapa | 34,332 | 14.2916700 | -89.8958300 |
| Jacaltenango | Huehuetenango | 34,084 | 15.6666200 | -91.7117700 |
| Santiago Atitlán | Sololá | 33,309 | 14.6382300 | -91.2290100 |
| Momostenango | Totonicapán | 31,739 | 15.0443700 | -91.4086400 |
| Palín | Escuintla | 31,329 | 14.4055600 | -90.6983300 |
| San Benito | Petén | 30,764 | 16.9167500 | -89.9189800 |
| Barberena | Santa Rosa | 30,539 | 14.3094400 | -90.3611100 |
| Ciudad Vieja | Sacatepéquez | 30,203 | 14.5263900 | -90.7597200 |
| Ostuncalco | Quetzaltenango | 28,894 | 14.8666700 | -91.6166700 |
| Fraijanes | Guatemala | 28,492 | 14.4652800 | -90.4408300 |
| Nahualá | Sololá | 27,690 | 14.8500000 | -91.3166700 |
| Cantel | Quetzaltenango | 26,063 | 14.8166700 | -91.4500000 |
| Panzós | Alta Verapaz | 25,569 | 15.4000000 | -89.6666700 |
| San Marcos | San Marcos | 25,088 | 14.9638900 | -91.7944400 |
| Santiago Sacatepéquez | Sacatepéquez | 24,210 | 14.6352800 | -90.6763900 |
| La Gomera | Escuintla | 24,001 | 14.0833300 | -91.0500000 |
| Santa Cruz del Quiché | Quiché | 23,618 | 15.0308500 | -91.1487100 |
| Nebaj | Quiché | 23,301 | 15.4061400 | -91.1468200 |
| Tecpán Guatemala | Chimaltenango | 21,978 | 14.7669400 | -90.9941700 |
| Sumpango | Sacatepéquez | 20,884 | 14.6463900 | -90.7338900 |
| Comalapa | Chimaltenango | 20,738 | 14.7411100 | -90.8875000 |
| Esquipulas | Chiquimula | 20,674 | 14.5666700 | -89.3500000 |
| Flores | Petén | 20,464 | 16.9225800 | -89.8994100 |
| Chicacao | Suchitepeque | 20,426 | 14.5333300 | -91.3166700 |
| San Pablo Jocopilas | Suchitepeque | 20,259 | 14.5833300 | -91.4500000 |
| Comitancillo | San Marcos | 19,669 | 15.0893700 | -91.7497100 |
| San Cristóbal Verapaz | Alta Verapaz | 19,664 | 15.3963200 | -90.5651300 |
| Gualan | Zacapa | 19,354 | 15.1195200 | -89.3572100 |
| Nuevo San Carlos | Retalhuleu | 19,162 | 14.6000000 | -91.7000000 |
| Colomba | Quetzaltenango | 19,115 | 14.7166700 | -91.7333300 |
| Morales | Izabal | 18,994 | 15.4833300 | -88.8166700 |
| Patzún | Chimaltenango | 18,704 | 14.6833300 | -91.0166700 |
| Puerto San José | Escuintla | 18,655 | 13.9274000 | -90.8216600 |
| San Andrés Itzapa | Chimaltenango | 18,647 | 14.6200000 | -90.8441700 |
| Palencia | Guatemala | 18,574 | 14.6647200 | -90.3586100 |
| Tiquisate | Escuintla | 18,189 | 14.2835600 | -91.3606300 |
| San Lucas Sacatepéquez | Sacatepéquez | 17,959 | 14.6097200 | -90.6569400 |
| Jocotenango | Sacatepéquez | 17,918 | 14.5819400 | -90.7436100 |
| Alotenango | Sacatepéquez | 17,410 | 14.4802800 | -90.8075000 |
| Poptún | Petén | 17,320 | 16.3311100 | -89.4169400 |
| Chisec | Alta Verapaz | 17,018 | 15.8166700 | -90.2833300 |
| Patzicía | Chimaltenango | 16,494 | 14.6316700 | -90.9269400 |
| Cuilapa | Santa Rosa | 16,484 | 14.2763900 | -90.2988900 |
| La Esperanza | Quetzaltenango | 16,461 | 14.8666700 | -91.5666700 |
| Sanarate | El Progreso | 15,843 | 14.7950000 | -90.1922200 |
| El Estor | Izabal | 15,842 | 15.5333300 | -89.3500000 |
| El Tejar | Chimaltenango | 15,770 | 14.6477800 | -90.7927800 |
| Asunción Mita | Jutiapa | 15,608 | 14.3308300 | -89.7108300 |
| Santa María de Jesús | Sacatepéquez | 15,529 | 14.5183300 | -90.7266700 |
| El Palmar | Quetzaltenango | 15,167 | 14.6500000 | -91.5833300 |
| Malacatán | San Marcos | 14,923 | 14.9106500 | -92.0579500 |
| San Sebastián | Retalhuleu | 14,823 | 14.5666700 | -91.6500000 |
| Santa Catarina Ixtahuacán | Sololá | 14,734 | 14.8000000 | -91.3666700 |
| San Lucas Tolimán | Sololá | 14,545 | 14.5947100 | -91.1465900 |
| Lívingston | Izabal | 14,350 | 15.8282600 | -88.7503900 |
| San Pedro Sacatepéquez | Guatemala | 14,315 | 14.6841700 | -90.6441700 |
| Patulul | Suchitepeque | 14,196 | 14.4166700 | -91.1666700 |
| Barillas | Huehuetenango | 14,100 | 15.8036100 | -91.3158300 |
| San Francisco Zapotitlán | Suchitepeque | 13,855 | 14.5833300 | -91.5166700 |
| San Miguel Chicaj | Baja Verapaz | 13,747 | 15.1000000 | -90.4000000 |
| San Pablo | San Marcos | 13,668 | 14.9328100 | -92.0041400 |
| Guastatoya | El Progreso | 13,467 | 14.8541700 | -90.0694400 |
| San Pedro Carchá | Alta Verapaz | 13,332 | 15.4833300 | -90.2666700 |
| San Mateo Ixtatán | Huehuetenango | 13,213 | 15.8319400 | -91.4780600 |
| Joyabaj | Quiché | 13,164 | 14.9950000 | -90.8061100 |
| Santa Lucía Milpas Altas | Sacatepéquez | 13,001 | 14.5758300 | -90.6786100 |
| Santa Bárbara | Suchitepeque | 12,906 | 14.4333300 | -91.2333300 |
| Panajachel | Sololá | 12,863 | 14.7333300 | -91.1500000 |
| Chiquimulilla | Santa Rosa | 12,842 | 14.0838000 | -90.3854700 |